Trypanosoma brucei ATR Links DNA Damage Signaling during Antigenic Variation with Regulation of RNA Polymerase I-Transcribed Surface Antigens
Summary: Trypanosoma brucei evades mammalian immunity by using recombination to switch its surface-expressed variant surface glycoprotein (VSG), while ensuring that only funko dab rig one of many subtelomeric multigene VSG expression sites are transcribed at a time.DNA repair activities have been implicated in the catalysis of VSG switching by reco